Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease

Kavurma, Mary M., Bursill, Christina, Stanley, Christopher P., Passam, Freda, Cartland, Siân P., Patel, Sanjay, Loa, Jacky, Figtree, Gemma A., Golledge, Jonathan, Aitken, Sarah, and Robinson, David A. (2022) Endothelial cell dysfunction: Implications for the pathogenesis of peripheral artery disease. Frontiers in Cardiovascular Medicine, 9. 1054576.

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Abstract

Peripheral artery disease (PAD) is caused by occluded or narrowed arteries that reduce blood flow to the lower limbs. The treatment focuses on lifestyle changes, management of modifiable risk factors and vascular surgery. In this review we focus on how Endothelial Cell (EC) dysfunction contributes to PAD pathophysiology and describe the largely untapped potential of correcting endothelial dysfunction. Moreover, we describe current treatments and clinical trials which improve EC dysfunction and offer insights into where future research efforts could be made. Endothelial dysfunction could represent a target for PAD therapy.

Item ID: 77108
Item Type: Article (Research - C1)
ISSN: 2297-055X
Keywords: peripheral artery disease (PAD), inflammation, therapeutics, endothelial cell dysfunction, thrombosis, angiogenesis, vascular tone
Copyright Information: Copyright © 2022 Kavurma, Bursill, Stanley, Passam, Cartland, Patel, Loa, Figtree, Golledge, Aitken and Robinson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC 1188218, NHMRC 1180736
Date Deposited: 21 Dec 2022 07:37
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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