Traumatic Brain Injury Rehabilitation : An Exercise Immunology Perspective

Singaravelu Jaganathan, Kannan, and Sullivan, Karen A. (2022) Traumatic Brain Injury Rehabilitation : An Exercise Immunology Perspective. Exercise Immunology Review, 28. pp. 47-57. (In Press)

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Traumatic brain injury (TBI) is the largest cause of death and disability globally. The physical and psychosocial consequences after TBI can persist for prolonged periods, and lead to increased health care and economic burden. Exercise has shown promise over recent years as a mode of rehabilitation that alleviates multiple TBI symptoms; but there is a lack of controlled large-scale studies and limited research into the underlying mechanisms. This critical review draws from animal and human studies on exercise immunology to speculate on possible mechanisms that could underlie beneficial outcomes of exercise after TBI. The anti-inflammatory role of exercise, protective role offered by pre-injury exercise, and the need for more objective studies on biomarker analysis are expected to be useful considerations to develop optimal post-TBI exercise rehabilitation programs. Future studies can consider investigating the specific immunological processes induced by exercise in consideration of individual differences and non-aerobic exercise modalities.

Item ID: 77074
Item Type: Article (Research - C1)
ISSN: 1077-5552
Keywords: exercise immunology, neuroinflammation, traumatic brain injury
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Copyright Information: Copyright © 2022 International Society of Exercise and Immunology. All rights reserved.
Date Deposited: 20 Dec 2022 04:02
FoR Codes: 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology @ 60%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320499 Immunology not elsewhere classified @ 40%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50%
20 HEALTH > 2003 Provision of health and support services > 200399 Provision of health and support services not elsewhere classified @ 50%
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