Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches

González García, Laura E., MacGregor, Melanie, Cavallaro, Alex, Koynov, Kaloian, and Vasilev, Krasimir (2022) Plasma polymer barrier layers to control the release kinetics from dissolvable microneedle patches. Plasma Processes and Polymers, 19 (12). 2200099.

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Dissolving microneedles are a noninvasive transdermal drug delivery platform that offers painless needle-free patient treatment. Current strategies to control the kinetics of drug release from the polymeric microneedle patches consist of adjusting the bulk polymer formulations and/or encapsulating the cargo in controlled delivery vehicles. Instead, in this study, the drug release rates were altered by modifying the surface properties of the microneedles using plasma polymer coatings with tailored properties. The main advantage of this one-step, solvent-free, and scalable method is that it can be applied to any type of microneedles regardless of their drug cargo or bulk material. Octadiene plasma polymer films were found to suppress the burst release effect of otherwise rapidly dissolving microneedles and to reduce the dissolution rate by a factor of four compared to uncoated control patches. The approach presented in this study offers an alternative, highly tunable, and customizable strategy for controlling drug release rate from microneedle patches.

Item ID: 77017
Item Type: Article (Research - C1)
ISSN: 1612-8869
Keywords: drug release, microneedle, octadiene, plasma polymers
Copyright Information: © 2022 Wiley‐VCH GmbH.
Funders: National Health and Medical Research Council (NHMRC), Australian Research Council (ARC)
Projects and Grants: NHMRC GNT1194466, ARC DP180101254, ARC FT200100301
Date Deposited: 28 Feb 2023 06:26
FoR Codes: 40 ENGINEERING > 4016 Materials engineering > 401609 Polymers and plastics @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321404 Pharmaceutical delivery technologies @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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