A practical guide to promote informatics-driven efficient biotopographic material development

Guo, Yuanlong, Mi, Jiaomei, Ye, Chen, Ao, Yong, Shi, Mengru, Shan, Zhengjie, Li, Bingzhi, Chen, Zetao, Chen, Zhuofan, Vasilev, Krasimir, and Xiao, Yin (2022) A practical guide to promote informatics-driven efficient biotopographic material development. Bioactive Materials, 8. pp. 515-528.

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Micro/nano topographic structures have shown great utility in many biomedical areas including cell therapies, tissue engineering, and implantable devices. Computer-assisted informatics methods hold great promise for the design of topographic structures with targeted properties for a specific medical application. To benefit from these methods, researchers and engineers require a highly reusable “one structural parameter – one set of cell responses” database. However, existing confounding factors in topographic cell culture devices seriously impede the acquisition of this kind of data. Through carefully dissecting the confounding factors and their possible reasons for emergence, we developed corresponding guideline requirements for topographic cell culture device development to remove or control the influence of such factors. Based on these requirements, we then suggested potential strategies to meet them. In this work, we also experimentally demonstrated a topographic cell culture device with controlled confounding factors based on these guideline requirements and corresponding strategies. A “guideline for the development of topographic cell culture devices” was summarized to instruct researchers to develop topographic cell culture devices with the confounding factors removed or well controlled. This guideline aims to promote the establishment of a highly reusable “one structural parameter – one set of cell responses” database that could facilitate the application of informatics methods, such as artificial intelligence, in the rational design of future biotopographic structures with high efficacy.

Item ID: 77014
Item Type: Article (Research - C1)
ISSN: 2452-199X
Keywords: Biotopographic materials, Cell culture device, Confounding factor, Database, Informatics
Copyright Information: © 2021 The Authors. Publishing services by Elsevier B.V. on behalf of Ke Ai Communications Co. Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0).
Date Deposited: 01 Mar 2023 00:18
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320699 Medical biotechnology not elsewhere classified @ 50%
40 ENGINEERING > 4003 Biomedical engineering > 400399 Biomedical engineering not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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