The role of serotonin and glutathione in the pathogenesis of chytridiomycosis
Claytor, Sieara Clarice (2020) The role of serotonin and glutathione in the pathogenesis of chytridiomycosis. PhD thesis, James Cook University.
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Abstract
Sieara Claytor studied the effect of serotonin and glutathione in the pathogenesis of the frog-killing fungus Batrachochytrium dendrobatidis (Bd). She found that serotonin inhibits Bd growth in vitro and Bd uses protein glutathionylation to protect an important glycolytic protein. This is will aid in developing future therapeutics.
| Item ID: | 76800 |
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| Item Type: | Thesis (PhD) |
| Keywords: | 5-hydroxytryptamine, aspartyl protease, Batrachochytrium dendrobatidis, chytridiomycosis, Crinia signifera, enolase, fungalysin metallopeptidase, glutathione, Philoria frosti, protein S-glutathionylation, Pseudophryne corroboree, Rhinella marina, serine peptidase, serotonin, tryptophan |
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| Copyright Information: | Copyright © 2020 Sieara Clarice Claytor. |
| Additional Information: | One publication arising from this thesis is stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publication is: [Chapter 2] Claytor, Sieara C., Gummer, Joel P.A., Grogan, Laura F., Skerratt, Lee F., Webb, Rebecca J., Brannelly, Laura A., Berger, Lee, and Roberts, Alexandra A. (2019) Susceptibility of frogs to chytridiomycosis correlates with increased levels of immunomodulatory serotonin in the skin. Cellular Microbiology, 21 (10). e13089. |
| Date Deposited: | 16 Nov 2022 00:13 |
| FoR Codes: | 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310705 Mycology @ 50% 31 BIOLOGICAL SCIENCES > 3109 Zoology > 310905 Animal immunology @ 30% 31 BIOLOGICAL SCIENCES > 3101 Biochemistry and cell biology > 310103 Cell metabolism @ 20% |
| SEO Codes: | 18 ENVIRONMENTAL MANAGEMENT > 1806 Terrestrial systems and management > 180602 Control of pests, diseases and exotic species in terrestrial environments @ 50% 18 ENVIRONMENTAL MANAGEMENT > 1806 Terrestrial systems and management > 180606 Terrestrial biodiversity @ 50% |
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