Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros

Ritmejeryte, Edita, Ryan, Rachael Y.M., Byatt, Brendan J., Peck, Yoshimi, Yeshi, Karma, Daly, Norelle L., Zhao, Guangzu, Crayn, Darren, Loukas, Alex, Pyne, Stephen G., Ruscher, Roland, and Wangchuk, Phurpa (2022) Anti-inflammatory properties of novel galloyl glucosides isolated from the Australian tropical plant Uromyrtus metrosideros. Chemico-Biological Interactions, 368. 110124.

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Two new galloyl glucosides, galloyl-lawsoniaside A (4) and uromyrtoside (6), were isolated from the polar fraction of Uromyrtus metrosideros leaf extract along with another four previously identified phytochemicals (1, 2, 3, and 5). The structures of these six compounds were characterised using low and high-resolution mass spectrometry (L/HRMS) and 1D and 2D Nuclear Magnetic Resonance (NMR) spectroscopy. These compounds were not toxic to human peripheral blood mononuclear cells (PBMCs) at 10 μg/mL over 24 h, yet showed significant in vitro suppression of proinflammatory cytokines involved in the pathogenesis of inflammatory bowel disease (IBD). Specifically, the release of interferon γ (IFN-γ), interleukin (IL)-17A, and IL-8 from phorbol myristate acetate/ionomycin (P/I) and anti-CD3/anti-CD28-activated cells were significantly suppressed by compounds 4 and 5. Interestingly, no effect on tumour necrosis factor (TNF) release was observed. These results show that the newly characterised compound 4 has promising cytokine suppressive properties, which could be further investigated as a candidate for IBD treatment.

Item ID: 76785
Item Type: Article (Research - C1)
ISSN: 1872-7786
Keywords: Uromyrtus metrosideros, Phytochemical, Galloyl glucoside, Cytotoxicity, Anti-Inflammatory, Inflammatory bowel disease
Copyright Information: 2022 Elsevier B.V. All rights reserved
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC APP1183323
Date Deposited: 15 Nov 2022 05:36
FoR Codes: 34 CHEMICAL SCIENCES > 3405 Organic chemistry > 340502 Natural products and bioactive compounds @ 80%
41 ENVIRONMENTAL SCIENCES > 4101 Climate change impacts and adaptation > 410102 Ecological impacts of climate change and ecological adaptation @ 20%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 80%
28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280111 Expanding knowledge in the environmental sciences @ 20%
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