Gird your kidneys? A novel approach to ADPKD therapeutics

Mallett, Andrew (2023) Gird your kidneys? A novel approach to ADPKD therapeutics. Journal of Nephrology, 36. pp. 933-934.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: https://doi.org/10.1007/s40620-022-01425...
 
1


Abstract

[Extract] The need remains high to identify new and novel treatments for autosomal dominant polycystic kidney disease (ADPKD), especially those that might slow the rate of decline of kidney function given that it is the most common heritable form of chronic kidney disease [1]. The first directed therapy for ADPKD has generated substantial impact as the evidence for its efficacy and role has accumulated [2]. Tolvaptan has however been associated with some challenges to implementation due to symptoms, side effects, and variability in licensing and/or funding across different jurisdictions globally. Consequently, substantial activity continues in order to identify additional therapeutic approaches to ameliorate or slow ADPKD pathobiology and clinical sequelae [3]. To date, the vast majority, if not all of these approaches that have been investigated in preclinical models or clinical trials have been pharmacological interventions.

Item ID: 76593
Item Type: Article (Short Note)
ISSN: 1724-6059
Copyright Information: © The Author(s) under exclusive licence to Italian Society of Nephrology 2022.
Date Deposited: 31 Mar 2023 06:33
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page