Haycocknema perplexum myositis: The first description of subclinical disease and a proposed distinctive triad to evoke clinical suspicion
Ward, Kayla, Krishnan, Anirudh, Iyengar, Krishnan R., Robertson, Thomas, White, Richard, and Urkude, Ravindra (2022) Haycocknema perplexum myositis: The first description of subclinical disease and a proposed distinctive triad to evoke clinical suspicion. BMJ Neurology Open, 4 (1). e000290.
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Abstract
Introduction: Haycocknema perplexum is an exceedingly rare cause of parasitic myositis endemic to Australia, more specifically, Tasmania and North Queensland. There is a paucity of literature regarding this diagnosis, with only nine previously described cases.
Diagnosis: This report details two cases of biopsy-confirmed H. perplexum myositis from Townsville University Hospital and describes the first-ever case of subclinical infection. There is limited known information regarding the H. perplexum life cycle and a definitive host which has hindered the development of a non-invasive diagnostic test. A review of the previously described cases has identified the hallmark features of this enigmatic condition: a triad of serological markers including deranged hepatic function, persistent eosinophilia and an elevated creatine kinase.
Conclusions: This report aimed to raise awareness of H. perplexum myositis and the possibility of subclinical infection, which suggests a protracted disease course. Further research is required to identify a non-invasive diagnostic test, given that early diagnosis and timely initiation of albendazole treatment may drastically limit patient disability.
Item ID: | 76536 |
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Item Type: | Article (Research - C1) |
ISSN: | 2632-6140 |
Keywords: | INFECTIOUS DISEASES, MUSCLE, NEUROMUSCULAR, NEUROPATHOLOGY, TROPICAL NEUROLOGY |
Copyright Information: | © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
Date Deposited: | 26 Apr 2023 23:24 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320211 Infectious diseases @ 100% |
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