Leicht, Anthony S., Boullosa, Daniel A., and Hautala, Arto J. (2017) Commentaries on point: Counterpoint: exercise training-induced bradycardia. Journal of Applied Physiology, 123 (3). p. 693.

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Abstract

To the editor: Boyett et al. (4) and Billman (2) provide compelling arguments for and against exercise-training induced bradycardia being due to altered sinus node function. Boyett and colleagues, through a series of elegant experiments have demonstrated that exercise training in mice reduces intrinsic heart rate (5). In similar experiments, Billman et al. (1) showed that exercise training in dogs does not reduce intrinsic heart rate. The easiest explanation for these contrasting results as pointed out by Billman is that murine and canine physiology are different. This raises the question: how applicable are either of these studies to humans?

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