Cannabinoid Therapeutics in orofacial pain management: A Systematic Review

Votrubec, C., Tran, P., Lei, A., Brunet, Z., Bean, L., Olsen, B.W., and Sharma, D. (2022) Cannabinoid Therapeutics in orofacial pain management: A Systematic Review. Australian Dental Journal. (In Press)

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Abstract

The objective of this paper is to investigate the published evidence regarding effects of cannabinoids (natural and synthetic) on post-operative and/or out-of-office pain management in patients suffering from orofacial pain that presents in the dental setting. Three online databases (Ovid (MEDLINE), PubMed (MEDLINE), Scopus) were searched (July 2021). Additional studies were sought through grey literature searching (Cochrane Library Trials and ClinicalTrials.gov) and hand-searching the reference lists of included articles. All studies that analysed cannabinoid products and pain management of conditions that present in the general or specialist dental setting in the English language were included. Of the five articles included, one reported a significant effect on temporomandibular disorder pain relief using a topical cannabidiol formulation compared to a placebo. Four articles reported no significant effects of cannabinoids for pain management across various orofacial pain conditions. Although one study reported a positive effect, insufficient evidence exists to support a tangible clinical benefit of cannabinoids in managing orofacial pain, further research is recommended to investigate the benefits of cannabinoids' use. © 2022 Australian Dental Association.

Item ID: 76159
Item Type: Article (Research - C1)
ISSN: 1834-7819
Keywords: Orofacial pain, analgesia, cannabis, cannabinoids, cannabidiol, marijuana
Copyright Information: © 2022 The Authors. Australian Dental Journal published by John Wiley & Sons Australia, Ltd on behalf of Australian Dental Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Date Deposited: 05 Oct 2022 23:36
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320312 Special needs dentistry @ 70%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 30%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200103 Human pain management @ 70%
20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 30%
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