The Evolving Role of Diagnostic Genomics in Kidney Transplantation
Soraru, Jacqueline, Chakera, Aron, Isbel, Nikky, Mallawaarachichi, Amali, Rogers, Natasha, Trnka, Peter, Patel, Chirag, and Mallett, Andrew J. (2022) The Evolving Role of Diagnostic Genomics in Kidney Transplantation. Kidney International Reports, 7 (8). pp. 1758-1771.
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Abstract
Monogenic forms of heritable kidney disease account for a significant proportion of chronic kidney disease (CKD) across both pediatric and adult patient populations and up to 11% of patients under 40 years reaching end-stage kidney failure (KF) and awaiting kidney transplant. Diagnostic genomics in the field of nephrology is ever evolving and now plays an important role in assessment and management of kidney transplant recipients and their related donor pairs. Genomic testing can help identify the cause of KF in kidney transplant recipients and assist in prognostication around graft survival and rate of recurrence of primary kidney disease. If a gene variant has been identified in the recipient, at-risk related donors can be assessed for the same and excluded if affected. This paper aims to address the indications for genomic testing in the context for kidney transplantation, the technologies available for testing, the conditions and groups in which testing should be most often considered, and the role for the renal genetics multidisci-plinary team in this process.
Item ID: | 76108 |
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Item Type: | Article (Research - C1) |
ISSN: | 2468-0249 |
Keywords: | genetic kidney disease, kidney transplant, whole exome sequencing, whole genome sequencing, diagnostic genomics |
Copyright Information: | © 2022 International Society of Nephrology. Published by Elsevier Inc. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
Date Deposited: | 28 Sep 2022 07:34 |
FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320214 Nephrology and urology @ 100% |
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