Longitudinal association between caesarean section birth and cardio-vascular risk profiles among adolescents in Australia

Begum, Tahmina, Fatima, Yaqoot, Anuradha, Satyamurthy, Hasan, Md, and Al Mamun, Abdullah (2022) Longitudinal association between caesarean section birth and cardio-vascular risk profiles among adolescents in Australia. Australian and New Zealand Journal of Public Health, 46 (6). pp. 776-783.

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Objective: To examine the association of cesarean section (C-section) with cardiovascular disease (CVD) risk biomarkers among Australian children.

Methods: The Longitudinal Study of Australian Children (LSAC) birth cohort was prospectively followed for body mass index (BMI) trajectory, and then linked with CVD risk indicators of children; waist circumference (WC), systolic blood pressure (SBP), blood glucose, high-density lipoprotein (HDL), triglyceride (TG), fat mass index (FMI) and composite metabolic syndrome (CMetS) score. Multivariable linear regression analysis was done to assess the association of C-sections with CVD risk biomarkers.

Results: Of 1,874 study children, 30% had C-sections; the mean age (SD) was 11.50 (0.50) years, and 49% were female. Against the vaginally-born cohort, Caesarean-born children showed a higher Z- score for five of the seven CVD risk indicators in regression analysis; WC (0.15; p=0.003), SBP (0.16; p=0.003), inverse HDL (0.15; p=0.003), FMI (0.12; p=0.004), and CMetS (0.45; p=0.004) score. Children with accelerated BMI trajectory had higher CMetS scores for both the delivery types while the C-section cohort showed statistical association only (1.69; p=0.006)

Conclusion: C-section was independently associated with increased CVD risk profiles of children, further increased with high BMI trajectory.

Implication for public health: The chronic disease risk of C-sections should be discussed with families to reduce clinically unrequired C-sections.

Item ID: 75822
Item Type: Article (Research - C1)
ISSN: 1753-6405
Keywords: cardiovascular risk, continuous metabolic syndrome score, caesarean section birth, adolescents, developed country
Copyright Information: © 2022 The Authors This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
Funders: Australian Research Council (ARC)
Projects and Grants: ARC CE200100025
Date Deposited: 24 Aug 2022 08:30
FoR Codes: 42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care @ 50%
42 HEALTH SCIENCES > 4203 Health services and systems > 420317 Patient safety @ 50%
SEO Codes: 20 HEALTH > 2004 Public health (excl. specific population health) > 200408 Injury prevention and control @ 100%
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