Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes

Wang, Yutang, Fang, Yan, Magliano, Dianna J., Charchar, Fadi J., Sobey, Christopher G., Drummond, Grant R., and Golledge, Jonathan (2023) Fasting triglycerides are positively associated with cardiovascular mortality risk in people with diabetes. Cardiovascular Research, 119 (3). pp. 826-834.

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Aims: We investigated the association of fasting triglycerides with cardiovascular disease (CVD) mortality.

Methods and results: This cohort study included US adults from the National Health and Nutrition Examination Surveys from 1988 to 2014. CVD mortality outcomes were ascertained by linkage to the National Death Index records. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of triglycerides for CVD mortality. The cohort included 26 570 adult participants, among which 3978 had diabetes. People with higher triglycerides had a higher prevalence of diabetes at baseline. The cohort was followed up for a mean of 12.0 years with 1492 CVD deaths recorded. A 1-natural-log-unit higher triglyceride was associated with a 30% higher multivariate-adjusted risk of CVD mortality in participants with diabetes (HR, 1.30; 95% CI, 1.08–1.56) but not in those without diabetes (HR, 0.95; 95% CI, 0.83–1.07). In participants with diabetes, people with high triglycerides (200–499 mg/dL) had a 44% (HR, 1.44; 95% CI, 1.12–1.85) higher multivariate-adjusted risk of CVD mortality compared with those with normal triglycerides (<150 mg/dL). The findings remained significant when diabetes was defined by fasting glucose levels alone, or after further adjustment for the use of lipid-lowering medications, or after the exclusion of those who took lipid-lowering medications.

Conclusion: This study demonstrates that fasting triglycerides of ≥200 mg/dL are associated with an increased risk of CVD mortality in patients with diabetes but not in those without diabetes. Future clinical trials of new treatments to lower triglycerides should focus on patients with diabetes.

Item ID: 75816
Item Type: Article (Research - C1)
ISSN: 1755-3245
Keywords: Hypertriglyceridaemia, Mortality, CVD, Diabetes, Risk factor
Funders: National Health and Medical Research Council of Australia (NHMRC).
Projects and Grants: NHMRC 1062671
Date Deposited: 24 Aug 2022 07:38
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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