Willson, Annie, and Jordan, Margaret (2023) Cellular Cytotoxicity and Multiple Sclerosis. In: Anil, Sukumaran, (ed.) Cytotoxicity. IntechOpen, London, United Kingdom, pp. 69-90.

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Abstract

Multiple sclerosis (MS) is an autoimmune disease in which discrete central nervous system lesions result from perivascular immune cell infiltration associated with damage to myelin (demyelination), oligodendrocytes and neurons. This culminates in debilitating neurological symptoms, primarily affecting women in their child-bearing years. Both the innate and adaptive branches of the immune system have been implicated in disease initiation and progression, and although the underlying cause remains elusive, there is compelling evidence for a complex interaction between genetic and environmental factors, leading to inflammation and neurodegeneration. Both direct cellular toxicity and antibody-dependent cellular cytotoxicity (ADCC) involving several cell types have been identified in playing major roles. These cells and their interactions in the pathogenesis of MS will be discussed.

Item ID:	75410
Item Type:	Book Chapter (Scholarly Work)
ISBN:	978-1-80356-246-9
Copyright Information:	© 2022 The Author(s). Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders:	National Health and Medical Research Council (NHMRC)
Projects and Grants:	NHMRC Research Betty Cuthbert Fellowship
Date Deposited:	18 Aug 2022 05:23
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320406 Immunogenetics (incl. genetic immunology) @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320403 Autoimmunity @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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