Babesiosis Vaccines: Lessons Learned, Challenges Ahead, and Future Glimpses

Rathinasamy, Vignesh, Poole, William A., Bastos, Reginaldo G., Suarez, Carlos E., and Cooke, Brian M. (2019) Babesiosis Vaccines: Lessons Learned, Challenges Ahead, and Future Glimpses. Trends in Parasitology, 35 (8). pp. 622-635.

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Abstract

The incidence and prevalence of babesiosis in animals and humans is increasing, yet prevention, control, or treatment measures remain limited and ineffective. Despite a growing body of new knowledge of the biology, pathogenicity, and virulence of Babesia parasites, there is still no well-defined, adequately effective and easily deployable vaccine. While numerous published studies suggest that the development of such anti-Babesia vaccines should be feasible, many others identify significant challenges that need to be overcome in order to succeed. Here, we review historic and recent attempts in babesiosis vaccine discovery to avoid past pitfalls, learn new lessons, and provide a roadmap to guide the development of next-generation babesiosis vaccines.

Item ID: 75285
Item Type: Article (Research - C1)
ISSN: 1471-5007
Copyright Information: © Elsevier.
Funders: Australian Research Council (ARC)
Projects and Grants: ARC DP180102584
Date Deposited: 12 Jul 2022 01:56
FoR Codes: 30 AGRICULTURAL, VETERINARY AND FOOD SCIENCES > 3009 Veterinary sciences > 300909 Veterinary parasitology @ 100%
SEO Codes: 10 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 1001 Environmentally sustainable animal production > 100199 Environmentally sustainable animal production not elsewhere classified @ 40%
10 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 1004 Livestock raising > 100401 Beef cattle @ 30%
10 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 1004 Livestock raising > 100402 Dairy cattle @ 30%
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