The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma

Spann, Kirsten, Snape, Natale, Baturcam, Engin, and Fantino, Emmanuelle (2016) The Impact of Early-Life Exposure to Air-borne Environmental Insults on the Function of the Airway Epithelium in Asthma. Annals of Global Health, 82 (1). pp. 28-40.

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DOI: 10.1016/j.aogh.2016.01.007

View at Publisher Website: https://doi.org/10.1016/j.aogh.2016.01.0...

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Abstract

The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.


Item ID:	74894
Item Type:	Article (Research - C1)
ISSN:	2214-9996
Keywords:	air pollution, airway remodeling, allergens, asthma, early life, epithelium, immunity, virus
Copyright Information:	© 2016 The Authors. Published by Elsevier Inc. on behalf of Icahn School of Medicine at Mount Sinai. This is an open access article under the CC BY-NC-ND license http://creativecommons.org/licenses/by-nc-nd/4.0/).
Date Deposited:	25 Oct 2022 05:56
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321302 Infant and child health @ 20% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320103 Respiratory diseases @ 30% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320401 Allergy @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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