Pharmacist Involvement in Cancer Pain Management: A Systematic Review and Meta-Analysis

Shrestha, Sunil, KC, Bhuvan, Blebil, Ali Qais, and Teoh, Siew Li (2022) Pharmacist Involvement in Cancer Pain Management: A Systematic Review and Meta-Analysis. Journal of Pain, 23 (7). pp. 1123-1142.

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This review aimed to critically evaluate the impact of pharmacist involvement in managing pain in cancer patients. Databases (including MEDLINE, Embase and CENTRAL) were searched with a broad search strategy for studies involving pharmacists and cancer pain management until February 10, 2021. The quality of studies and evidence were assessed using standardized tools and GRADE, respectively. A random-effects model was used for meta-analysis. Sixty-four studies were included. Common interventions delivered by the pharmacists were medication review, patient education, adverse drug reactions (ADRs) detection and management, pharmacological recommendations (in dosing and pharmacotherapy choice), and pain assessment. A pooled analysis of 3 randomized control trials showed a significant reduction in pain intensity with a standardized mean difference (SMD) of 0.35 [95% confidence intervals (CI): -0.55, -0.16]. Pooled analyses from nonrandomized studies of interventions also showed significant results in reduction of ADRs with an odds ratio of 0.69 (95% CI: 0.61, 0.79) and improvement in quality of life with SMD of 0.80 (95% CI: 0.29, 1.32). Thus, pharmacists significantly improve the clinical outcomes of cancer patients related to pain. This indicates the involvement of pharmacists directly or in collaboration with healthcare professionals in the oncology team is highly beneficial for the patients.

Perspectives: This systematic review presents a comprehensive evaluation of pharmacist involvement in cancer pain management. This shows the importance of direct involvement of the pharmacist or as an important member of the multidisciplinary oncology team.

Item ID: 74728
Item Type: Article (Research - C1)
ISSN: 1528-8447
Keywords: Adverse drug reaction, cancer pain, medication review, pain intensity, pharmacist
Copyright Information: © 2022 by United States Association for the Study of Pain, Inc.
Date Deposited: 01 Dec 2022 06:14
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321403 Clinical pharmacy and pharmacy practice @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200103 Human pain management @ 100%
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