Allostatic load and systemic comorbidities in psychiatric disorders

Finlay, Sabine, Rudd, Donna, McDermott, Brett, and Sarnyai, Zoltan (2022) Allostatic load and systemic comorbidities in psychiatric disorders. Psychoneuroendocrinology, 140. 105726.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Psychiatric disorders are complex, disabling, and chronic conditions that are often accompanied by one or more systemic medical comorbidities. In this narrative review, we provide an overview of the allostatic load concept, which represents a multi-system dysregulation in response to chronic stress and link it to systemic comorbidities associated with psychiatric disorders. We synthesized published literature gathered using Medline (Ovid), Scopus, and PsychInfo and identified a high frequency of systemic comorbidities for both mood and psychotic disorders. The identified cardiovascular, metabolic, and immune comorbidities may represent the result of chronic wear and tear caused by a complex interaction between chronic psychosocial stress, health risk behaviors, pharmacological stressors, and the biological systems involved in the development of allostatic load. These findings support the notion that psychiatric disorders should be re-conceptualized as systemic disorders, affecting the brain and systemic biological pathways in an interconnected fashion to result in systemic comorbidities. We suggest that the multi-systemic and multi-dimensional approach that drives the allostatic load concept should be considered for understanding comorbidities in vulnerable psychiatric patients.

Item ID: 74484
Item Type: Article (Research - C1)
ISSN: 1873-3360
Keywords: Allostatic load, Comorbidities, Mental health, Psychiatric disorders
Copyright Information: © 2022 Elsevier Ltd. All rights reserved.
Date Deposited: 27 Oct 2022 00:48
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320221 Psychiatry (incl. psychotherapy) @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page