Nanomaterial-based label-free electrochemical aptasensors for the detection of thrombin

Yousef, Hibba, Liu, Yang, and Zheng, Lianxi (2022) Nanomaterial-based label-free electrochemical aptasensors for the detection of thrombin. Biosensors, 12 (4). 253.

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Thrombin plays a central role in hemostasis and its imbalances in coagulation can lead to various pathologies. It is of clinical significance to develop a fast and accurate method for the quantitative detection of thrombin. Electrochemical aptasensors have the capability of combining the specific selectivity from aptamers with the extraordinary sensitivity from electrochemical techniques and thus have attracted considerable attention for the trace-level detection of thrombin. Nanomaterials and nanostructures can further enhance the performance of thrombin aptasensors to achieve high sensitivity, selectivity, and antifouling functions. In highlighting these material merits and their impacts on sensor performance, this paper reviews the most recent advances in label-free electrochemical aptasensors for thrombin detection, with an emphasis on nanomaterials and nanostructures utilized in sensor design and fabrication. The performance, advantages, and limitations of those aptasensors are summarized and compared according to their material structures and compositions.

Item ID: 73633
Item Type: Article (Research - C1)
ISSN: 2079-6374
Copyright Information: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://
Date Deposited: 16 May 2022 00:40
FoR Codes: 34 CHEMICAL SCIENCES > 3401 Analytical chemistry > 340103 Electroanalytical chemistry @ 80%
34 CHEMICAL SCIENCES > 3401 Analytical chemistry > 340108 Sensor technology (incl. chemical aspects) @ 20%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 100%
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