Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data

Harkus, Uasim, Wankell, Miriam, Palamuthusingam, Pranavan, McFarlane, Craig McFarlane, and Hebbard, Lionel (2022) Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data. Seminars in Cancer Biology, 86 (3). pp. 799-815.

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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer related deaths in the world, and for patients with advanced disease there are few therapeutic options available. The complex immunological microenvironment of HCC and the success of immunotherapy in several types of tumours, has raised the prospect of potential benefit for immune based therapies, such as immune checkpoint inhibitors (ICIs), in HCC. This has led to significant breakthrough research, numerous clinical trials and the rapid approval of multiple systemic drugs for HCC by regulatory bodies worldwide. Although some patients responded well to ICIs, many have failed to achieve significant benefit, while others showed unexpected and paradoxical deterioration. The aim of this review is to discuss the pathophysiology of HCC, the tumour microenvironment, key clinical trials evaluating ICIs in HCC, various resistance mechanisms to ICIs, and possible ways to overcome these impediments to improve patient outcomes.

Item ID: 73439
Item Type: Article (Research - C1)
ISSN: 1096-3650
Copyright Information: © 2022 Elsevier Ltd. All rights reserved.
Funders: THHS Study Education and Research Trust Account (SERTA), Gastroenterological Society of Australia (GESA)
Date Deposited: 01 Jun 2022 04:15
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321111 Solid tumours @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320409 Tumour immunology @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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