Tocotrienols Supplementation Ameliorated Neurofunctions and Motor Deficits in 6-OHDA Induced Rat Model of Parkinsonism: A Behavioral and Immunohistochemistry Analysis

Kumari, Mangala, Ramdas, Premdas, Radhakrishnan, Ammu, Methil, Kannan Kutty, and Nagaraja, Haleagrahara (2021) Tocotrienols Supplementation Ameliorated Neurofunctions and Motor Deficits in 6-OHDA Induced Rat Model of Parkinsonism: A Behavioral and Immunohistochemistry Analysis. Nutrients, 13 (5). 1583.

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Abstract

Parkinson's disease (PD) is a debilitating neurodegenerative disease, which progresses over time, causing pathological depigmentation of the substantia nigra (SN) in the midbrain due to loss of dopaminergic neurons. Emerging studies revealed the promising effects of some nutrient compounds in reducing the risk of PD. One such nutrient compound that possess neuroprotective effects and prevents neurodegeneration is tocotrienol (T3), a vitamin E family member. In the present study, a single dose intracisternal injection of 250 µg 6-hydroxydopamine (6-OHDA) was used to induce parkinsonism in male Sprague Dawley (SD) rats. Forty-eight hours post injection, the SD rats were orally supplemented with alpha (α)- and gamma (γ)-T3 for 28 days. The neuroprotective effects of α- and γ-T3 were evaluated using behavioural studies and immunohistochemistry (IHC). The findings from this study revealed that supplementation of α- and γ-T3 was able to ameliorate the motor deficits induced by 6-OHDA and improve the neuronal functions by reducing inflammation, reversing the neuronal degradation, and preventing further reduction of dopaminergic neurons in the SN and striatum (STR) fibre density.

Item ID: 73219
Item Type: Article (Research - C1)
ISSN: 2072-6643
Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Date Deposited: 10 May 2022 23:55
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3209 Neurosciences > 320903 Central nervous system @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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