Oral squamous cell carcinoma frequency in young patients from referral centers around the world

Ferreira e Costa, Rafael, Leão, Marina Luiza Baião, Sant’Ana, Maria Sissa Pereira, Mesquita, Ricardo Alves, Gomez, Ricardo Santiago, Santos-Silva, Alan Roger, Khurram, Syed Ali, Tailor, Artysha, Schouwstra, Ciska-Mari, Robinson, Liam, van Heerden, Willie F. P., Tomasi, Ramiro Alejandro, Gorrino, Romina, de Prato, Ruth Salomé Ferreyra, Taylor, Adalberto Mosqueda, Urizar, José Manuel Aguirre, de Mendoza, Irene Lafuente Ibañez, Radhakrisnan, Raghu, Chandrashekar, Chetana, Choi, Siu-Wai, Thomson, Peter, Pontes, Hélder Antônio Rebelo, and Fonseca, Felipe Paiva (2022) Oral squamous cell carcinoma frequency in young patients from referral centers around the world. Head and Neck Pathology. (In Press)

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Abstract

Oral squamous cell carcinoma (OSCC) commonly affects older patients; however, several studies have documented an increase in its incidence among younger patients. Therefore, it is important to investigate if this trend is also found in different geographic regions. The pathology files of diagnostic and therapeutic institutions from different parts of the globe were searched for OSCC cases diagnosed from 1998 to 2018. Data regarding the sex, age, and tumor location of all cases, as well as the histologic grade and history of exposure to risk habits of cases diagnosed as OSCC in young patients (≤ 40 years of age) were obtained. The Chi-square test was used to determine any increasing trend. A total of 10,727 OSCC cases were identified, of which 626 cases affected young patients (5.8%). Manipal institution (India) showed the highest number of young patients (13.2%). Males were the most affected in both age groups, with the tongue and floor of the mouth being the most affected subsites. OSCC in young individuals were usually graded as well or moderately differentiated. Only 0.9% of the cases occurred in young patients without a reported risk habit. There was no increasing trend in the institutions and the period investigated (p > 0.05), but a decreasing trend was observed in Hong Kong and the sample as a whole (p < 0.001). In conclusion there was no increase of OSCC in young patients in the institutions investigated and young white females not exposed to any known risk factor represented a rare group of patients affected by OSCC.

Item ID: 73217
Item Type: Article (Research - C1)
ISSN: 1936-0568
Keywords: Oral squamous cell carcinoma, Oral cancer, Young patients, Incidence, Prevalence, Epidemiology
Copyright Information: © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022
Date Deposited: 30 Mar 2022 00:29
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320307 Oral medicine and pathology @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2005 Specific population health (excl. Indigenous health) > 200599 Specific population health (excl. Indigenous health) not elsewhere classified @ 100%
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