Cellular and humoral responses in liver of cattle and buffaloes infected with a single dose of Fasciola gigantica

Molina, Elizabeth C., and Skerratt, Lee F. (2005) Cellular and humoral responses in liver of cattle and buffaloes infected with a single dose of Fasciola gigantica. Veterinary Parasitology, 131 (1-2). pp. 157-163.

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Abstract

The cellular components of the hepatic inflammatory infiltrate in cattle and buffaloes infected with a single dose of 1000 Fasciola gigantica were analysed by immunohistochemistry and histology. Tand B lymphocytes, plasma cells, eosinophils and mast cells were present in the hepatic lesions. It is proposed that both cellular and humoral immune responses were induced in the liver of cattle and buffaloes during infection with F. gigantica probably by antigens released by the developing flukes and by damage caused by the flukes during their migration in the liver. The local T cell response differed between these animals, with the response decreasing after 3 weeks post-infection in cattle in contrast to a gradually increasing response in buffaloes. Difference in the T cell response between cattle and buffaloes may be related to their differences in resistance and resilience to infection with F. gigantica.

Item ID: 7239
Item Type: Article (Research - C1)
ISSN: 1873-2550
Keywords: buffaloes; cattle; Fasciola gigantica; immune response; liver
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Date Deposited: 03 Mar 2010 05:34
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 100%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830301 Beef Cattle @ 100%
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