Artemisinin-class combination therapy for malaria-unresolved ethical and technical issues

Durrheim, David N. (2004) Artemisinin-class combination therapy for malaria-unresolved ethical and technical issues. Travel Medicine and Infectious Disease, 2 (3-4). pp. 185-188.

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DOI: 10.1016/j.tmaid.2004.04.003

View at Publisher Website: http://dx.doi.org/10.1016/j.tmaid.2004.0...

Abstract

Artemisinin-class Combination Therapy (ACT) remains the most plausible means by which the ambitious goal of halving malaria mortality by the year 2010 may be achieved. Convincing evidence of ACT efficacy in treating uncomplicated malaria now exists. ACT appears safe but most safety studies have been weak methodologically. Thus there is an acute need for sensitive ongoing pharmacovigilance. Limited availability of ACT in those countries most likely to benefit from its public health use, has resulted in allegations of ‘medical malpractice’ against the World Health Organization and Global Fund for AIDS, TB and malaria. The ethical principles of autonomy, sanctity of life, beneficence and justice are pertinent to the adoption of ACT as first-line therapy of uncomplicated malaria by endemic countries.


Item ID:	7211
Item Type:	Article (Research - C1)
ISSN:	1873-0442
Keywords:	artemisinin; Artemisinin-class Combination Therapy; ethics; malaria; treatment; pharmacovigilance
Date Deposited:	26 Mar 2010 03:31
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 50%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 51% 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 49%
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