Isolation of antibacterial depside constituents from Indonesian folious lichen, Candelaria fibrosa

Nugraha, Ari Satia, Dayli, Ikhar Ridho, Putri, Chintya Permata Zahky Sukrisno, Firli, Lilla Nur, Pratama, Antonius Nugraha Widhi, Triatmoko, Bawon, Untari, Ludmilla Fitri, Wongso, Hendris, Keller, Paul A., and Wangchuk, Phurpa (2022) Isolation of antibacterial depside constituents from Indonesian folious lichen, Candelaria fibrosa. Journal of Biologically Active Products from Nature, 12 (1). pp. 24-32.

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There is an urgent need for novel drug leads, especially for microbial infections due to continuing emergence of drug resistance. Natural products are the backbone of modern medicine and the lichens have an important role to play in the discovery of novel drugs. Indonesia is gifted with a diverse array of lichens, which remain underexplored for medicinal applications. In this study, we have collected a lichen, Candelaria fibrosa, and conducted phytochemical and bioactivity studies. Using high performance liquid chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy, we have isolated and characterised two depside compounds, atraric acid (7) and methyl 3-hydroxy orsellinate (8). These two depsides were reported from this lichen species for the first time. The evaluation of the crude methanol extract against Gram-positive bacteria, Staphylococcus aureus, indicated insignificant activity. However, the isolated compounds have been previously reported to possess low antimicrobial activity against common pathogenic bacteria (Staphylococcus aureus, Bacillus cereus and Pseudomonas aeruginosa) but to show significant anti-legionellosis.

Item ID: 72059
Item Type: Article (Research - C1)
ISSN: 2231-1874
Keywords: Candelaria fibrosa, atraric acid, methyl 3-hydroxy orsellinate, antibacterial, Staphylococcus aureus
Copyright Information: © 2021 Har Krishan Bhalla & Sons.
Date Deposited: 22 Feb 2022 00:31
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320701 Medical bacteriology @ 50%
34 CHEMICAL SCIENCES > 3404 Medicinal and biomolecular chemistry > 340401 Biologically active molecules @ 50%
SEO Codes: 28 EXPANDING KNOWLEDGE > 2801 Expanding knowledge > 280105 Expanding knowledge in the chemical sciences @ 80%
20 HEALTH > 2002 Evaluation of health and support services > 200299 Evaluation of health and support services not elsewhere classified @ 20%
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