The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis

Doma, Kenji, Singh, Utkars, Boullosa, Daniel, and Connor, Jonathan (2021) The effect of branched-chain amino acid on muscle damage markers and performance following strenuous exercise: a systematic review and meta-analysis. Applied Physiology, Nutrition and Metabolism, 46 (11). pp. 1303-1313.

[img]
Preview
PDF (Accepted Author Manuscript) - Accepted Version
Download (2MB) | Preview
View at Publisher Website: https://doi.org/10.1139/apnm-2021-0110
 
175


Abstract

This systematic review and meta-analysis determined whether the ergogenic effects of branched-chain amino acids (BCAA) ameliorated markers of muscle damage and performance following strenuous exercise. In total, 25 studies were included, consisting of 479 participants (age 24.3 6 8.3 years, height 1.73 6 0.06 m, body mass 70.8 6 9.5 kg, females 26.3%). These studies were rated as fair to excellent following the PEDro scale. The outcome measures were compared between the BCAA and placebo conditions at 24 and 48 hours following muscle-damaging exercises, using standardised mean differences and associated p-values via forest plots. Our meta-analysis demonstrated significantly lower levels of indirect muscle damage markers (creatine kinase, lactate dehydrogenase and myoglobin) at 48 hours post-exercise (standardised mean difference [SMD] = 0.41; p < 0.05) for the BCAA than placebo conditions, whilst muscle soreness was significant at 24 hours post-exercise (SMD = 0.28 ≤ d ≤ 0.61; p < 0.05) and 48 hours post-exercise (SMD = 0.41 ≤ d≤ 0.92; p [removed] 0.05). Overall, BCAA reduced the level of muscle damage biomarkers and muscle soreness following muscle-damaging exercises. However, the potential benefits of BCAA for muscle performance recovery is questionable and warrants further investigation to determine the practicality of BCAA for ameliorating muscle damage symptoms in diverse populations. PROSPERO registration number: CRD42020191248. Novelty: • BCAA reduces the level of creatine kinase and muscle soreness following strenuous exercise with a dose–response relationship. • BCAA does not accelerate recovery for muscle performance.

Item ID: 71545
Item Type: Article (Research - C1)
ISSN: 1715-5320
Keywords: creatine kinase; créatine kinase; douleur musculaire; isoleucine; leucine; muscle soreness; supplement; supplément; valine
Copyright Information: © 2021 The Author(s).
Date Deposited: 08 Feb 2022 04:50
FoR Codes: 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology @ 50%
42 HEALTH SCIENCES > 4207 Sports science and exercise > 420799 Sports science and exercise not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
Downloads: Total: 175
Last 12 Months: 138
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page