Investigating the immunomodulatory properties of the hookworm recombinant secretome
Ryan, Stephanie Margaret (2019) Investigating the immunomodulatory properties of the hookworm recombinant secretome. PhD thesis, James Cook University.
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Abstract
Stephanie generated over 100 hookworm proteins, assessed their anti-inflammatory properties in a murine colitis model and further validated the top leads in a human peripheral blood mononuclear cell (PBMC) assay. This work produced a novel, rapid drug discovery pipeline and a comprehensive library of hookworm derived immunotherapeutics for treating inflammatory bowel disease (IBD).
| Item ID: | 71538 |
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| Item Type: | Thesis (PhD) |
| Keywords: | hookworms, anti-inflammatory, colitis, inflammatory bowel disease, IBD, immunotherapeutics |
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| Copyright Information: | Copyright © 2019 Stephanie Margaret Ryan. |
| Additional Information: | For this thesis, Stephanie Ryan received the Dean's Award for Excellence 2020, which recognises excellence in Higher Degree by Research and recipients of this award are commended by independent expert examiners as having made a substantial contribution to their field of research. One publication arising from this thesis is stored in ResearchOnline@JCU, at the time of processing. Please see the Related URLs. The publication is: Chapter 1: Ryan, Stephanie M., Eichenberger, Ramon M., Ruscher, Roland, Giacomin, Paul R., and Loukas, Alex (2020) Harnessing helminth-driven immunoregulation in the search for novel therapeutic modalities. PLoS Pathogens, 16 (5). e1008508. |
| Date Deposited: | 04 Feb 2022 02:41 |
| FoR Codes: | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3207 Medical microbiology > 320704 Medical parasitology @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3204 Immunology > 320402 Applied immunology (incl. antibody engineering, xenotransplantation and t-cell therapies) @ 50% |
| SEO Codes: | 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100% |
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