Systematic review of the effects of sodium-glucose cotransporter 2 inhibitors on hospitalization for heart failure and cardiac structure or function, and exploratory assessment of potential mechanisms

Rasalam, Roy, Atherton, John J., Deed, Gary, Molloy-Bland, Michael, Cohen, Neale, and Sindone, Andrew (2021) Systematic review of the effects of sodium-glucose cotransporter 2 inhibitors on hospitalization for heart failure and cardiac structure or function, and exploratory assessment of potential mechanisms. In: [Presented at the Australasian Diabetes Congress 2021]. From: Australasian Diabetes Congress 2021 (ADS/ADEA Annual Scientific Meeting), 11-13 August 2021, Online.

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Abstract

In the past 5 years, there has been a profound shift in the therapeutic focus of trials of sodium-glucose cotransporter 2 inhibitors (SGLT2is).

Although initially explored and introduced as glucose-lowering agents for patients with type 2 diabetes mellitus (T2DM), 1 clinical investigation of these molecules has evolved towards heart failure (HF) and chronic kidney disease (CKD) outcomes in patients with and without T2DM.

We systematically reviewed randomized controlled trial (RCT) data assessing the effects of SGLT2 is compared with placebo on hospitalization for HF (HHF), cardiac structure and cardiac function, in a PRISMA-compliant manner.

We also reviewed, in an exploratory manner, mechanistic evidence for how SGLT2 is may exert their benefits.

Item ID: 71285
Item Type: Conference Item (Poster)
Keywords: sodium glucose contransporter2 inhibitor; heart failure; type 2 diabetes
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Date Deposited: 18 Jan 2022 21:49
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 60%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320208 Endocrinology @ 40%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 40%
20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 60%
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