Furyk, J., George, S., Phillips, N., O'Brien, S., Emeto, T., and Babl, F. (2020) First results from the status Epilepticus Australasian registry for children (SEARCh). Multicentre, prospective, observational cohort study of paediatric status epilepticus. Emergency Medicine Australasia, 32 (S1). pp. 60-61.

PDF (Abstract Only) - Published Version Restricted to Repository staff only

Abstract

Background: Status Epilepticus (SE) is the most frequent neurological emergency in children, with a high morbidity and mortality. There are no prospective national Australian emergency department (ED) data on SE.

Objective: To determine clinical characteristics and management of SE in children in Australian EDs.

Methods: Prospective, observational cohort study at 4 mixed and tertiary paediatric ED in Australia. Participants were included if presenting with SE (seizure duration >5 min). We present descriptive data on clinical characteristics and management as medians (IQR) using APLS dosing as gold standard.

Results: 172 children were enrolled: age 4.0 years (1.8 to 8.5), weight 18.0 kg (12.3 to 26.8) and 50.0% were male. Seizure duration was 15.0 min (7.0 to 40.0). The majority of patients arrived by ambulance (73.8%) and had a history of prior seizures/epilepsy (67.4%).

Benzodiazepines were administered by parents/caregivers 45/172 (26.2%), prehospital 58/172 (33.7%) and in ED, 43/172 (25.0%) and were administered after seizure onset at 12.5 min (7–18.1), 13.1 min (9.3–19.3) and 125 min (70–250) respectively.

Median doses of benzodiazepines were 0.2 mg (0.1–0.3) and 0.2 (0.1–0.2). Second line drugs (phenytoin or leviteracetam) was administered in ED 21/172 (12.2%) of patients at 125.0 min (70.0–250.0). On discharge, the most common diagnosis was convulsive SE and focal motor SE with prominent motor signs. Disposition included 6.9% ICU and 93.1% ward.

Conclusion: Children with SE are generally treated as per APLS guidelines. However, there is a large scope for earlier treatment with both benzodiazepines and second line drugs.

Item ID:	71232
Item Type:	Article (Abstract)
ISSN:	1742-6723
Copyright Information:	Editorial material and organization © 2020 Australasian College for Emergency Medicine. Copyright of individual abstracts remains with the authors.
Additional Information:	Presented at: the ACEM 2019 Annual Scientific Meeting: The Changing Climate of Emergency Medicine, 17–21 November 2019, Hobart, TAS, Australia.
Date Deposited:	31 Jan 2022 22:04
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320207 Emergency medicine @ 60% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3213 Paediatrics > 321302 Infant and child health @ 40%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 50% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50%
Downloads:	Total: 1
	More Statistics