Interactions of osteoprogenitor cells with a novel zirconia implant surface

Munro, Thomas, Sharma, Dileep, Miller, Catherine, and Dos Santos Antunes, Elsa (2020) Interactions of osteoprogenitor cells with a novel zirconia implant surface. In: [Presented at the 98th General Session & Exhibition of the IADR/49th Annual Meeting & Exhibition of the AADR]. 2296. From: 98th General Session & Exhibition of the IADR/49th Annual Meeting & Exhibition of the AADR, 18-21 March 2020, Washington, D.C., USA.

[img] PDF (Abstract Only) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Objectives: This study evaluated the in-vitro response of a mouse pre-osteoblast cellline on a novel, sandblasted zirconia surface compared to titanium.

Methods: The novel zirconia surface was created by sandblasting at 6cm with 150-200μm alumina particles under 0.6MPa pressure, for 3 minutes. MC3T3-E1 subclone 4osteoblast precursor cell line was cultured on either sandblasted titanium (SBCpTi) orsandblasted zirconia (SBY-TZP). The surface topography was analysed by three-dimensional laser microscopy measurements and scanning electron microscope. The chemical state of each surface was also assessed using wettability measurements. The cellular response was quantied by morphology (day 1), proliferation (day 1, 3, 5, 7, 9),viability (day 1, 9) and migration (0, 6, 24 hours).

Results: The sandblasting surface treatment was successful for both titanium andzirconia, increasing surface roughness and obtaining a defi ned surface topography ,however, titanium was able to achieve a more apparent nano-topography. Thewettability of the two surfaces showed no significant difference. The zirconia surface resulted in improved cellular spreading and a significantly increased rate of migration compared to titanium. However, cellular proliferation and viability of the cell line was not significantly different on the two surfaces.

Conclusions: The novel, roughened zirconia surface elicited cell stimulating propertiescomparable or exceeding that of titanium. Therefore, this novel zirconia surface can bean acceptable substitute for titanium as a dental implant material. Further in vitro andin vivo animal studies would be important to further assess zirconia and this novelsurface as suitable for dental implants and an alternative to titanium-based dentalimplants; prior to clinical studies.

Item ID: 70995
Item Type: Conference Item (Abstract / Summary)
Keywords: Zirconia; Dental Implants; Osteoblasts
Related URLs:
Date Deposited: 28 Nov 2021 23:53
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320306 Oral implantology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page