Local delivery of VEGF-Hydrogel in developing MRONJ lesion modulates socket healing and systemic cytokine response

Sharma, Chakrabhavi Gundurao Dileep, Hamlet, Stephen, and Ivanovski, Saso (2017) Local delivery of VEGF-Hydrogel in developing MRONJ lesion modulates socket healing and systemic cytokine response. In: [Presented at the 57th Annual Scientific Meeting of the IADR ANZ Division]. 0391. From: 57th Annual Scientific Meeting of the IADR ANZ Division, 25-27 September 2017, Adelaide,SA, Australia.

PDF (Abstract Only) - Published Version
Restricted to Repository staff only

View at Publisher Website: https://iadr.abstractarchives.com/abstra...

Abstract

Objectives: Aetiopathogenesis of medication-related osteonecrosis of the jaw (MRONJ)was classically considered to involve direct suppression of osteoclast-induced boneremodelling and cytotoxic effects of Zoledronic acid (ZA). However, recent literaturepoints towards local and systemic suppression of angiogenesis contributing to thisprocess. Hence, this study was designed to examine the effect of locally delivered EGF-hydrogel on in situ angiogenesis and systemic cytokine response.

Methods: VEGF-165 loaded hydrogel was used in ZA-induced rat MRONJ, followingextraction of maxillary molars and creation of a defect. After four weeks rats were sacrificed and gross examination and histological assessment were conducted to evaluate effect of of VEGF. Histological assessment involved quantification of osteonecrotic areas, inflammatory infiltrate otal vascularity (von Willebrand Factor, vWF immunostaining) and microvessel density (CD105). Furthermore, to assess thesystemic response induced by VEGF gel, peripheral (plasma) cytokine assay wasperformed using multiplex ELISA analysis.


Item ID:	70994
Item Type:	Conference Item (Abstract / Summary)
Keywords:	Hydrogel; Bisphosphonates; VEGF; Zoledronic acid; Angiogenesis
Related URLs:	Organisation
Date Deposited:	29 Nov 2021 23:15
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320399 Dentistry not elsewhere classified @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100%
Downloads:	Total: 1
	More Statistics

Actions (Repository Staff Only)

Item Control Page