Sharma, Chakrabhavi Gundurao Dileep (2015) Proangiogenic therapy as a treatment modality in the management of BRONJ. In: Abstracts from 55th Annual Scientific Meeting of the IADR ANZ Division. 193641. pp. 102-103. From: 55th Annual Scientific Meeting of the IADR ANZ Division, 23-26 August 2015, Dunedin, New Zealand.

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Abstract

Objectives: Bisphosphonates (BPs) are known to have a direct effect on the local vasculature, but their effect on the differentiation of progenitor cells into endothelial cells, which may ultimately contribute to the pathogenesis of bisphosphonate- related osteonecrosisof the jaw (BRONJ), is unknown. This study evaluated both the in-vitro effect(s) of differing potency bisphosphonates on the differentiation of human placenta-derived mesenchymal stem cells (pMSCs) into an endothelial lineage and the in vivo effect of locally delivered VEGF on a healing extraction socket in a BRONJ rat model.

Item ID:	70992
Item Type:	Conference Item (Abstract / Summary)
Keywords:	Hydrogel; Bisphosphonates; VEGF; Zoledronic acid
Related URLs:	Organisation
Date Deposited:	01 Dec 2021 03:57
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320399 Dentistry not elsewhere classified @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 50%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100%
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