Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression

Domschke, Katharina, Hohoff, Christa, Mortensen, Lena S., Roehrs, Tilmann, Deckert, Jurgen, Arolt, Volker, and Baune, Bernhard T. (2008) Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32 (1). pp. 224-228.

[img] PDF (Published Version)
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1016/j.pnpbp.2007.0...
 
50
1


Abstract

The monoamine oxidase A (MAO-A) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of Major Depression.

In the present study, 340 patients with a Major Depressive Episode (f = 194, m = 146; DSM-IV) of Caucasian descent were genotyped for the functional MAO-A VNTR. The clinical response to antidepressive pharmacological treatment was assessed by weekly intra-individual changes of HAM-D-21 scores over six weeks.

The longer MAO-A alleles (3a, 4, 5) conferred a significant risk of slower and less efficient overall response over the course of 6 weeks of antidepressant treatment in patients with Major Depression, with the effect being restricted to female patients (p = 0.028; corrected for multiple testing).

The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression.

Item ID: 7072
Item Type: Article (Research - C1)
ISSN: 0278-5846
Keywords: antidepressant treatment; Major Depression; monoamine oxidase A; paharmacogenetics; VNTR
Date Deposited: 20 Mar 2010 01:19
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page