Domschke, Katharina, Hohoff, Christa, Mortensen, Lena S., Roehrs, Tilmann, Deckert, Jurgen, Arolt, Volker, and Baune, Bernhard T. (2008) Monoamine oxidase A variant influences antidepressant treatment response in female patients with Major Depression. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 32 (1). pp. 224-228.

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Abstract

The monoamine oxidase A (MAO-A) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of Major Depression.

In the present study, 340 patients with a Major Depressive Episode (f = 194, m = 146; DSM-IV) of Caucasian descent were genotyped for the functional MAO-A VNTR. The clinical response to antidepressive pharmacological treatment was assessed by weekly intra-individual changes of HAM-D-21 scores over six weeks.

The longer MAO-A alleles (3a, 4, 5) conferred a significant risk of slower and less efficient overall response over the course of 6 weeks of antidepressant treatment in patients with Major Depression, with the effect being restricted to female patients (p = 0.028; corrected for multiple testing).

The present results suggest that high-activity MAO-A genotypes possibly by consecutively decreased serotonin and/or norepinephrine availability negatively influence antidepressant treatment response during the first six weeks of pharmacological treatment in female patients with Major Depression.

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