Association of Diagnosis of Depression and Small Abdominal Aortic Aneurysm Growth

Thanigaimani, Shivshankar, Phie, James, Quigley, Frank, Bourke, Michael, Bourke, Bernie, Velu, Ramesh, Jenkins, Jason, and Golledge, Jonathan (2022) Association of Diagnosis of Depression and Small Abdominal Aortic Aneurysm Growth. Annals of Vascular Surgery, 79. pp. 256-263.

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Background: Depression is associated with an increased risk of cardiovascular events but its association with abdominal aortic aneurysm (AAA) progression is unknown. This study examined if a diagnosis of depression was association with more rapid AAA growth.

Methods: Patients with small AAA measuring between 30 and 50 mm were recruited from surveillance programs at 4 Australian centres. Maximum AAA diameter was measured by ultrasound imaging using a standardised and reproducible protocol to monitor AAA growth. Depression was defined from medical records of treatment for depression at recruitment. Linear mixed effects modelling was performed to examine the independent association of depression with AAA growth. A propensity matched sub-analysis was performed.

Results: A total of 574 participants were included of whom 73 (12.7%) were diagnosed with depression. Participants were followed with a median of 3 (Inter-quartile range (IQR): 2, 5) ultrasound scans for a median of 2.1 (IQR: 1.1, 3.5) years. The unadjusted model suggested that annual AAA growth was non-significantly reduced (mean difference: -0.3 mm/year; 95% confidence interval (CI): -0.7, 0.2; P = 0.26) in participants with a diagnosis of depression compared to other participants. After adjustment for covariates, depression was not significantly associated with AAA growth (mean difference: -0.3 mm/year; 95% CI: -0.8, 0.2; P = 0.27). Findings were similar in the propensity matched sub-analysis. Sensitivity analyses investigating the impact of initial AAA diameter and follow up on the association of depression with AAA growth found no interaction.

Conclusions: This study suggested that depression was not associated with faster AAA growth.

Item ID: 70567
Item Type: Article (Research - C1)
ISSN: 1615-5947
Copyright Information: © 2021 Elsevier Inc. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC 1180736, NHMRC 1022752, NHMRC Practitioner Fellowship 1117061
Date Deposited: 01 Jun 2022 03:24
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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