Immune system investigation using parasitic helminths

Douglas, Bonnie, Oyesola, Oyebola, Cooper, Martha M., Posey, Avery, Tait Wojno, Elia, Giacomin, Paul R., and Herbert, De'Broski (2021) Immune system investigation using parasitic helminths. Annual Review of Immunology, 39. pp. 639-665.

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Coevolutionary adaptation between humans and helminths has developed a finely tuned balance between host immunity and chronic parasitism due to immunoregulation. Given that these reciprocal forces drive selection, experimental models of helminth infection are ideally suited for discovering how host protective immune responses adapt to the unique tissue niches inhabited by these large metazoan parasites. This review highlights the key discoveries in the immunology of helminth infection made over the last decade, from innate lymphoid cells to the emerging importance of neuroimmune connections. A particular emphasis is placed on the emerging areas within helminth immunology where the most growth is possible, including the advent of genetic manipulation of parasites to study immunology and the use of engineered T cells for therapeutic options. Lastly,we cover the status of human challenge trials with helminths as treatment for autoimmune disease, which taken together, stand to keep the study of parasitic worms at the forefront of immunology for years to come.

Item ID: 70451
Item Type: Article (Research - C1)
ISSN: 1545-3278
Keywords: animal models, helminth, innate immunity, lymphocytes, neuroimmunology, transgenesis
Copyright Information: © 2021 by Annual Reviews. All rights reserved
Date Deposited: 21 Feb 2022 23:09
FoR Codes: 31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310702 Infectious agents @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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