Penner, Hannah, and Hariharan, Gopakumar (2021) Comparative efficacy of levetiracetam to phenobarbital in the treatment of neonatal seizures. Acta Paediatrica, 110 (7). pp. 2287-2288.

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Abstract

[Extract] Neonatal seizures pose a diagnostic and therapeutic challenge in neonatal care.1 Prolonged seizures are associated with developmental and cognitive impairment and higher neonatal mortality.2 Rapid recognition and effective treatment are essential in reducing these harmful impacts on the developing brain.3

Neonatal seizures often lack definitive clinical features and are under- or overdiagnosed.4 Although continuous electroencephalogram (cEEG) remains the diagnostic gold standard, poor availability and resource-intensive nature limit its routine use in many neonatal units.2, 3 Furthermore, the controversy regarding the endpoints of neonatal seizure management (clinical or electroencephalographic) is not resolved.

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