Rao, Varsha, and Hariharan, Gopakumar (2021) Early-onset SARS-CoV-2 infection in neonates born to COVID positive mothers. Acta Paediatrica, 110 (8). pp. 2480-2481.

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Abstract

[Extract] The global pandemic caused by Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) has affected a substantial number of pregnant women.1 Although neonates have been reported to be positive for the virus infection, there is paucity of data on outcome and mode of transmission.

The predominant mode of transmission of SARS-CoV-2 is aerosol or direct contact.2, 3 Evidence suggests that respiratory viruses are not commonly transmitted in-utero. Although vertical transmission has been postulated as a mode of transmission in early-onset SARS-CoV-2 infection in neonates, there is no conclusive evidence to support this due to limitations related to sensitivity and specificity of diagnostic testing, variation in timing of tests for the virus and appropriate sample to determine infection conclusively.4 Furthermore, there is lack of consensus regarding definition of vertical transmission.

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