Systematic review and meta-analysis of Mendelian randomisation analyses of abdominal aortic aneurysms

Ibrahim, Muhammad, Thanigaimani, Shivshankar, Singh, Tejas P., Morris, Dylan, and Golledge, Jonathan (2021) Systematic review and meta-analysis of Mendelian randomisation analyses of abdominal aortic aneurysms. IJC Heart and Vasculature, 35. 100836.

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Introduction: Mendelian randomisation (MR) has been suggested to be able to overcome biases of observational studies, but no meta-analysis is available on MR studies on abdominal aortic aneurysm (AAA). This systematic review and Meta-analysis examined the evidence of causal risk factors for AAA identified in MR studies. Methods: Publicly available databases were systematically searched for MR studies that reported any causal risk factors for AAA diagnosis. Meta-analyses were performed using random effect models and reported as odds ratio (OR) and 95% confidence intervals (CI). Study quality was assessed using a modified version of Strengthening the Reporting of Mendelian Randomisation Studies (STROBE-MR) guidelines. Results: Sixteen MR studies involving 34,050 patients with AAA and 2,205,894 controls were included. Meta-analyses suggested that one standard deviation increase in high density lipoprotein (HDL) significantly reduced (OR: 0.66, 95% CI: 0.61, 0.72) and one standard deviation increase in low density lipoprotein (LDL) significantly increased the risk (OR: 1.68, 95%, CI: 1.55, 1.82) of AAA. One standard deviation increase in triglycerides did not significantly increase the risk of AAA (OR: 1.21, 95% CI: 0.86, 1.71). Quality assessment suggested that ten and five studies were of low and moderate risk of bias respectively, with one study considered as high risk of bias. Conclusion: This meta-analysis suggests LDL and HDL are positive and negative casual risk factors for AAA.

Item ID: 70216
Item Type: Article (Research - C1)
ISSN: 2352-9067
Keywords: Abdominal aortic aneurysm, Mendelian randomization, Peripheral artery disease
Copyright Information: This is an open access article under the CC BY-NC-ND license (
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC 1117061
Date Deposited: 15 Mar 2022 02:56
Downloads: Total: 168
Last 12 Months: 61
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