Associations of osteocalcin forms with metabolic syndrome and its individual components in older men: the health in men study

Liu, Xiaoying, Yeap, Bu B, Brock, Kaye E., Levinger, Itamar, Golledge, Jonathan, Flicker, Leon, and Brennan-Speranza, Tara C. (2021) Associations of osteocalcin forms with metabolic syndrome and its individual components in older men: the health in men study. Journal of Clinical Endocrinology and Metabolism, 106 (9). e3506-e3518.

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Abstract

Context: The osteoblast-derived polypeptide, osteocalcin (OC), has been associated with lower risk of type 2 diabetes and metabolic syndrome (MetS) in several epidemiological studies. Animal studies have indicated the undercarboxylated form of OC (ucOC) drives its association with metabolic outcomes.

Objective: We compared associations of ucOC and carboxylated OC (cOC) with MetS and its components in older men.

Methods: A cross-sectional analysis of 2575 men aged ≥70 years and older resident in Perth, Western Australia. ucOC was assayed using a hydroxyapatite-binding method, and cOC calculated by subtracting ucOC from total OC. Main outcome measures were MetS and its components.

Results: Both lower serum ucOC and cOC levels, and the proportion of cOC (%cOC) were associated with less favorable metabolic parameters (higher waist circumference, triglyceride, glucose, blood pressure, and lower high-density lipoprotein cholesterol), whereas inverse associations were found with %ucOC. Men in the lowest quintile of ucOC had higher risk of MetS compared to men in the highest quintile (Q1 ≤ 7.7 vs Q5 > 13.8 ng/mL; OR = 2.4; 95% CI, 1.8-3.2). Men in the lowest quintile of cOC had higher risk of MetS compared to those in the highest quintile (≤ 5.8 vs > 13.0 ng/mL; OR = 2.4; 95% CI, 1.8-3.2).

Conclusion: Lower concentrations of serum ucOC or cOC were associated with less favorable metabolic parameters and a higher risk of MetS. In contrast, a lower proportion of ucOC was associated with better metabolic parameters and lower MetS risk. Further research is warranted to determine whether ucOC and cOC are suitable biomarkers for cardiometabolic risk in men.

Item ID: 70144
Item Type: Article (Research - C1)
ISSN: 1945-7197
Keywords: carboxylated osteocalcin, metabolic syndrome, osteocalcin, undercarboxylated osteocalcin
Copyright Information: © The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved.
Funders: National Health and Medical Research Council (NHMRC)
Projects and Grants: NHMRC 1045710, NHMRC 1060557, NHMRC 1128083
Date Deposited: 01 Apr 2022 02:09
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320199 Cardiovascular medicine and haematology not elsewhere classified @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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