Local and systemic inflammation and oxidative stress after a single bout of maximal walking in patients with symptomatic peripheral artery disease

Andrade-Lima, Aluisio, Da Silva Junior, Natan, Chehuen, Marcel, Miyasato, Roberto, Souza, Rodrigo W.A., Leicht, Anthony S., Brum, Patricia C., De Oliveira, Edilamar M., Wolosker, Nelson, and Forjaz, Cláudia L.M. (2021) Local and systemic inflammation and oxidative stress after a single bout of maximal walking in patients with symptomatic peripheral artery disease. Journal of Cardiovascular Nursing, 36 (5). pp. 498-506.

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Abstract

Objective: The aim of this study was to assess the effects of a single bout of maximal walking on blood and muscle nitric oxide (NO) bioavailability, oxidative stress, and inflammation in symptomatic peripheral artery disease (PAD) patients.

Methods: A total of 35 men with symptomatic PAD performed a graded maximal exercise test on a treadmill (3.2 km/h, 2% increase in grade every 2 minutes). Plasma samples and gastrocnemius muscle biopsies were collected preexercise and postexercise for assessment of NO bioavailability (plasma NO and muscle, endothelial NO synthase), oxidative stress and antioxidant function (lipid peroxidation [LPO], catalase [CAT], and superoxide dismutase), and inflammation (interleukin-6, C-reactive protein, tumor necrosis factor-α, intercellular adhesion molecules, and vascular adhesion molecules). The effects of the walking exercise were assessed using paired t tests or Wilcoxon tests.

Results: After maximal walking, plasma NO and LPO were unchanged (P > .05), plasma CAT decreased, and all blood inflammatory markers increased (all P ≤ .05). In the disease-affected skeletal muscle, endothelial NO synthase, CAT, LPO, and all inflammatory markers increased, whereas superoxide dismutase decreased (all P ≤ .05).

Conclusion: In patients with symptomatic PAD, maximal exercise induces local and systemic impairments, which may play a key role in atherogenesis. Exercise strategies that avoid maximal effort may be important to reduce local and systemic damage and enhance clinical benefits.

Item ID: 70139
Item Type: Article (Research - C1)
ISSN: 1550-5049
Keywords: exercise, inflammation, intermittent claudication, NO bioavailability, oxidative stress
Copyright Information: Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.
Date Deposited: 26 Nov 2021 04:37
FoR Codes: 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology @ 40%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3201 Cardiovascular medicine and haematology > 320101 Cardiology (incl. cardiovascular diseases) @ 60%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200199 Clinical health not elsewhere classified @ 100%
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