Non-antimicrobial adjuvant strategies to tackle biofilm-related Staphylococcus aureus prosthetic joint infections

Pant, Narayan, and Eisen, Damon P. (2021) Non-antimicrobial adjuvant strategies to tackle biofilm-related Staphylococcus aureus prosthetic joint infections. Antibiotics, 10 (9). 1060.

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Abstract

Staphylococcus aureus frequently causes community-and hospital-acquired infections. S. aureus attachment followed by biofilm formation on tissues and medical devices plays a significant role in the establishment of chronic infections. Staphylococcal biofilms encase bacteria in a matrix and protect the cells from antimicrobials and the immune system, resulting in infections that are highly resistant to treatment. The biology of biofilms is complex and varies between organisms. In this review, we focus our discussion on S. aureus biofilms and describe the stages of their formation. We particularly emphasize genetic and biochemical processes that may be vulnerable to novel treatment approaches. Against this background, we discuss treatment strategies that have been successful in animal models of S. aureus biofilm-related infection and consider their possible use for the prevention and eradication of biofilm-related S. aureus prosthetic joint infection.

Item ID: 70135
Item Type: Article (Research - C1)
ISSN: 2079-6382
Keywords: Biofilm, Non-antimicrobial adjuvant, Prosthetic joint infections, Staphylococcus aureus
Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/4.0/).
Date Deposited: 30 Mar 2022 01:47
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3202 Clinical sciences > 320203 Clinical microbiology @ 100%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 100%
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