Association of pesticides and kidney function among adults in the US population 2001–2010

Wan, En Tzu, Darssan, Darsy, Karatela, Shamshad, Reid, Simon A., and Osborne, Nicholas John (2021) Association of pesticides and kidney function among adults in the US population 2001–2010. International Journal of Environmental Research and Public Health, 18 (19). 10249.

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Chronic kidney disease of unknown cause is prevalent in a range of communities; however, its etiology remains unclear. We examined the association between pesticide exposures and the risk of kidney function loss using four waves of the National Health and Nutrition Examination Survey (NHANES) to identify a pathological pathway. We pooled data from four cross-sectional waves of NHANES, with 41,847 participants in total. Exposure to malathion increased the risk of low kidney function (aOR = 1.26, 95% CI = 1.01–1.56) in the adjusted model. Increased risk of low kidney function was not found among those exposed to 2,4-D (aOR = 0.88, 95% CI = 0.72–1.09), 3,5,6-trichloropyridinol (aOR = 0.96, 95% CI = 0.83–1.12), and 3-PBA (aOR = 1.03, 95% CI = 0.94–1.13). Our findings provide evidence of altered kidney function in people exposed to malathion, highlighting the potential of organophosphate pesticides’ role in renal injury.

Item ID: 70060
Item Type: Article (Research - C1)
ISSN: 1660-4601
Keywords: Kidney function, Malathion, NHANES, Organophosphate insecticide, Pesticides
Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://
Date Deposited: 27 Apr 2022 22:45
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