Sharma, D., Hamlet, S., Petcu, E.B., and Ivanovski, S. (2018) Locally delivered bioactive agents as treatment modalities in the management of medication-induced osteonecrosis of the jaws. Australian Dental Journal, 63 (4). S12-S12.

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Abstract

Recent literature suggests that suppressed bone healing and angiogenesis contributes significantly to the pathogenesis of Medication induced osteonecrosis of jaws (MRONJ), a complex condition commonly associated with anti-resorptive agents. This in vitro study evaluated the effect of locally delivered angiogenic growth factor (VEGF165) with or without osteogenic growth factor (BMP-7) to enhance bone healing, thereby preventing the occurrence of MRONJ.

A chemically defined hydrogel (HyStem-HP, Glycosan Biosciences) containing a combination of thiolmodified hyaluronan, heparin and denatured collagen was crosslinked with thiol-reactive, PEGDA. To establish the in vitro release kinetics, 100 and 200 ng of rat VEGF165 (Biovision) or BMP-7 (250 and 500 ng/mL) was loaded into a 500 lL hydrogel prior to crosslinking (Hystem-HP).

Item ID:	69886
Item Type:	Article (Abstract)
ISSN:	1834-7819
Copyright Information:	© 2018 Australian Dental Association
Funders:	Australian Dental Research Foundation (ADRF)
Date Deposited:	01 Dec 2021 04:28
FoR Codes:	32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320312 Special needs dentistry @ 40% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 60%
SEO Codes:	20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50% 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 50%
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