Haematological, biochemical and hormonal biomarkers of heat intolerance in military personnel

Alele, Faith O., Malau-Aduli, Bunmi S., Malau-Aduli, Aduli E.O., and Crowe, Melissa J. (2021) Haematological, biochemical and hormonal biomarkers of heat intolerance in military personnel. Biology, 10 (10). 1068.

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Abstract

Heat intolerance is the inability to withstand heat stress and this may occur due to exertional heat stroke (EHS). However, it is unknown if heat intolerance is associated with immune and hormonal disturbances. This study investigates haematological, biochemical and hormonal biomarkers related to heat intolerance and EHS in military and civilian volunteers. A quasi-experimental pre-and post-test design was used, with participants drawn from the Australian Defence Force (ADF) and the general populace. Blood samples were collected and analysed for biomarkers. Inferential statistics compared the biomarkers between the groups. Changes in alanine amino transaminase (p = 0.034), creatine kinase (0.044), cortisol (p = 0.041) and creatinine (p < 0.001) differed between the heat-intolerant and heat-tolerant groups. Participants with a history of EHS showed significant changes in creatinine (p = 0.022) and urea (p = 0.0031) compared to those without EHS history. Predictors of heat intolerance were increasing post-HTT creatinine and cortisol (OR = 1.177, p = 0.011 and OR = 1.015, p = 0.003 respectively). Conclusively, EHS history is associated with changes in creatinine and urea concentrations, while the predictors of heat intolerance are creatinine and cortisol. However, further exploration of other biomarkers, such as genetic polymorphism, is needed.

Item ID: 69698
Item Type: Article (Research - C1)
ISSN: 2079-7737
Keywords: exertional heat illness; exertional heat stroke; heat tolerance; biomarkers; military
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Copyright Information: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Date Deposited: 19 Oct 2021 22:21
FoR Codes: 42 HEALTH SCIENCES > 4207 Sports science and exercise > 420702 Exercise physiology @ 50%
42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care @ 50%
SEO Codes: 14 DEFENCE > 1401 Defence > 140110 Personnel @ 50%
19 ENVIRONMENTAL POLICY, CLIMATE CHANGE AND NATURAL HAZARDS > 1901 Adaptation to climate change > 190101 Climate change adaptation measures (excl. ecosystem) @ 50%
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