Association of the COMT val158met variant with antidepressant treatment response in major depression

Baune, Bernhard, Hohoff, Christa, Berger, Klaus, Neumann, Anna, Mortensen, Sunke, Roehrs, Tilmann, Deckert, Jurgen, Arolt, Volker, and Domschke, Katharina (2008) Association of the COMT val158met variant with antidepressant treatment response in major depression. Neuropsychopharmacology, 33 (4). pp. 924-932.

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In several previous biochemical, pharmacological, and genetic studies, the catechol-O-methyltransferase (COMT) has been suggested to be involved in the pathogenesis as well as the pharmacological treatment of affective disorders. In the present study, 256 patients with major depression (DSM-IV) of Caucasian descent were genotyped for the functional COMT val158met polymorphism and characterized for clinical response to antidepressive pharmacological treatment as measured by intra-individual changes of Hamilton Depression (HAM-D-21) scores over 6 weeks. The COMT 158val/val genotype conferred a significant risk of worse response after 4–6 weeks of antidepressant treatment in patients with major depression (week 4: p=0.003; week 5: p<0.0001; week 6: p<0.0001) after Bonferroni correction for multiple comparisons. The present results strongly point toward a negative influence of the higher activity COMT 158val/val genotype on antidepressant treatment response during the first 6 weeks of pharmacological treatment in major depression, possibly conferred by consecutively decreased dopamine availability. This finding suggests a potentially beneficial effect of an antidepressive add-on therapy with substances increasing dopamine availability individually tailored according to COMT val158met genotype.

Item ID: 6955
Item Type: Article (Research - C1)
ISSN: 1740-634X
Keywords: major depression; catechol-o-methyltransferase; COMT val158met; polymorphism; antidepressants; treatment response
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Date Deposited: 02 Mar 2010 23:57
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 100%
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