Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians

Watts, Gerald F., Sullivan, David R., Hare, David L., Kostner, Karam M., Horton, Ari E., Bell, Damon A., Brett, Tom, Trent, Ronald J., Poplawski, Nicola K., Martin, Andrew C., Srinivasan, Shubha, Justo, Robert N., Chow, Clara K., Pang, Jing, and FH Australasia Network Consensus Working Group, (2021) Essentials of a new clinical practice guidance on familial hypercholesterolaemia for physicians. Internal Medicine Journal, 51 (5). pp. 769-779.

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Abstract

Familial hypercholesterolaemia (FH) is a common, heritable and preventable cause of premature coronary artery disease. New clinical practice recommendations are presented to assist practitioners in enhancing the care of all patients with FH. Core recommendations are made on the detection, diagnosis, assessment and management of adults, children and adolescents with FH. Management is under-pinned by the precepts of risk stratification, adherence to healthy lifestyles, treatment of non-cholesterol risk factors and appropriate use of low-density lipoprotein (LDL)-cholesterol-lowering therapies including statins, ezetimibe and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors. The recommendations need to be utilised using judicious clinical judgement and shared decision-making with patients and families. New government-funded schemes for genetic testing and use of PCSK9 inhibitors, as well as the National Health Genomics Policy Framework, will enable adoption of the recommendations. However, a comprehensive implementation science and practice strategy is required to ensure that the guidance translates into benefit for all families with FH.

Item ID: 69352
Item Type: Article (Scholarly Work)
ISSN: 1445-5994
Keywords: familial hypercholesterolaemia, guidance, care, management, adults, prevention
Copyright Information: © 2021 Royal Australasian College of Physicians
Additional Information:

Clare Heal is part of the FH Australasia Network Consensus Working Group. All collaborators are listed at the end of the article.

Date Deposited: 29 Sep 2021 03:58
FoR Codes: 42 HEALTH SCIENCES > 4203 Health services and systems > 420304 General practice @ 50%
42 HEALTH SCIENCES > 4206 Public health > 420605 Preventative health care @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200105 Treatment of human diseases and conditions @ 70%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 30%
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