Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis

Berthiller, Julien, Straif, Kurt, Agudo, Antonio, Ahrens, Wolfgang, Dos Santos, Alexandre Bezerra, Boccia, Stefania, Cadoni, Gabriella, Canova, Cristina, Castellsague, Xavier, Chen, Chu, Conway, David, Curado, Maria Paula, Maso, Luigino Dal, Daudt, Alexander W., Fabianova, Eleonora, Fernandez, Leticia, Franceschi, Silvia, Fukuyama, Erica E., Hayes, Richard B., Healy, Claire, Herrero, Rolando, Holcatova, Ivana, Kelsey, Karl, Kjaerheim, Kristina, Koifman, Sergio, Lagiou, Pagona, Vecchia, Carlo La, Lazarus, Philip, Levi, Fabio, Lissowska, Jolanta, MacFarlane, Tatiana, Mates, Dana, McClean, Michael, Menezes, Ana, Merletti, Franco, Morgenstern, Hal, Muscat, Joshua, Olshan, Andrew F., Purdue, Mark, Ramroth, Heribert, Rudnai, Peter, Schwartz, Stephen M., Serraino, Diego, Shangina, Oxana, Smith, Elaine, Sturgis, Erich M., Szeszenia-Dabrowska, Neonila, Thomson, Peter, Vaughan, Thomas L., Vilensky, Marta, Wei, Qingyi, Winn, Deborah M., Wünsch-Filho, Victor, Zhang, Zuo Feng, Znaor, Ariana, Ferro, Gilles, Brennan, Paul, Boffetta, Paolo, Hashibe, Mia, and Lee, Yuan Chin Amy (2016) Low frequency of cigarette smoking and the risk of head and neck cancer in the INHANCE consortium pooled analysis. International Journal of Epidemiology, 45 (3). pp. 835-845.

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Abstract

Background: Cigarette smoking is a major risk factor for head and neck cancer (HNC). To our knowledge, low cigarette smoking (<10 cigarettes per day) has not been extensively investigated in fine categories or among never alcohol drinkers.

Methods: We conducted a pooled analysis of individual participant data from 23 independent case-control studies including 19 660 HNC cases and 25 566 controls. After exclusion of subjects using other tobacco products including cigars, pipes, snuffed or chewed tobacco and straw cigarettes (tobacco product used in Brazil), as well as subjects smoking more than 10 cigarettes per day, 4093 HNC cases and 13 416 controls were included in the analysis. The lifetime average frequency of cigarette consumption was categorized as follows: never cigarette users, >0–3, >3–5, >5–10 cigarettes per day.

Results: Smoking >0–3 cigarettes per day was associated with a 50% increased risk of HNC in the study population [odds ratio (OR) ¼ 1.52, 95% confidence interval (CI): (1.21, 1.90). Smoking >3–5 cigarettes per day was associated in each subgroup from OR ¼ 2.01 (95% CI: 1.22, 3.31) among never alcohol drinkers to OR ¼ 2.74 (95% CI: 2.01, 3.74) among women and in each cancer site, particularly laryngeal cancer (OR ¼ 3.48, 95% CI: 2.40, 5.05). However, the observed increased risk of HNC for low smoking frequency was not found among smokers with smoking duration shorter than 20 years.

Conclusion: Our results suggest a public health message that low frequency of cigarette consumption contributes to the development of HNC. However, smoking duration seems to play at least an equal or a stronger role in the development of HNC.

Item ID: 68458
Item Type: Article (Research - C1)
ISSN: 1464-3685
Keywords: Head, Low frequency cigarette smoking, Neck cancer, Pooled analysis, Risk factors
Copyright Information: © The Author 2015; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association
Date Deposited: 04 Aug 2022 01:07
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320305 Oral and maxillofacial surgery @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2099 Other health > 209999 Other health not elsewhere classified @ 100%
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