Combined effects of smoking and HPV16 in oropharyngeal cancer

Anantharaman, Devasena, Muller, David C., Lagiou, Pagona, Ahrens, Wolfgang, Holcátová, Ivana, Merletti, Franco, Kjærheim, Kristina, Polesel, Jerry, Simonato, Lorenzo, Canova, Cristina, Castellsague, Xavier, Macfarlane, Tatiana V., Znaor, Ariana, Thomson, Peter, Robinson, Max, Conway, David I., Healy, Claire M., Tjønneland, Anne, Westin, Ulla, Ekström, Johanna, Chang-Claude, Jenny, Kaaks, Rudolf, Overvad, Kim, Drogan, Dagmar, Hallmans, Göran, Laurell, Göran, Bueno-de-Mesquita, H.B., Peeters, Petra H., Agudo, Antonio, Larrañaga, Nerea, Travis, Ruth C., Palli, Domenico, Barricarte, Aurelio, Trichopoulou, Antonia, George, Saitakis, Trichopoulos, Dimitrios, Quirós, J. Ramón, Grioni, Sara, Sacerdote, Carlotta, Navarro, Carmen, Sánchez, María José, Tumino, Rosario, Severi, Gianluca, Boutron-Ruault, Marie Christine, Clavel-Chapelon, Francoise, Panico, Salvatore, Weiderpass, Elisabete, Lund, Eiliv, Gram, Inger T., Riboli, Elio, Pawlita, Michael, Waterboer, Tim, Kreimer, Aimée R., Johansson, Mattias, and Brennan, Paul (2016) Combined effects of smoking and HPV16 in oropharyngeal cancer. International Journal of Epidemiology, 45 (3). pp. 752-761.

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Background: Although smoking and HPV infection are recognized as important risk factors for oropharyngeal cancer, how their joint exposure impacts on oropharyngeal cancer risk is unclear. Specifically, whether smoking confers any additional risk to HPV-positive oropharyngeal cancer is not understood.

Methods: Using HPV serology as a marker of HPV-related cancer, we examined the interaction between smoking and HPV16 in 459 oropharyngeal (and 1445 oral cavity and laryngeal) cancer patients and 3024 control participants from two large European multi-centre studies. Odds ratios and credible intervals [CrI], adjusted for potential confounders, were estimated using Bayesian logistic regression.

Results: Both smoking [odds ratio (OR [CrI]: 6.82 [4.52, 10.29]) and HPV seropositivity (OR [CrI]: 235.69 [99.95, 555.74]) were independently associated with oropharyngeal cancer. The joint association of smoking and HPV seropositivity was consistent with that expected on the additive scale (synergy index [CrI]: 1.32 [0.51, 3.45]), suggesting they act as independent risk factors for oropharyngeal cancer.

Conclusions: Smoking was consistently associated with increase in oropharyngeal cancer risk in models stratified by HPV16 seropositivity. In addition, we report that the prevalence of oropharyngeal cancer increases with smoking for both HPV16-positive and HPV16-negative persons. The impact of smoking on HPV16-positive oropharyngeal cancer highlights the continued need for smoking cessation programmes for primary prevention of head and neck cancer.

Item ID: 68457
Item Type: Article (Research - C1)
ISSN: 1464-3685
Keywords: Head and neck cancer risk, Human papillomavirus, Interaction, Oropharynx cancer, Tobacco smoking
Copyright Information: © The Author 2016; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
Date Deposited: 04 Aug 2022 02:11
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320305 Oral and maxillofacial surgery @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321199 Oncology and carcinogenesis not elsewhere classified @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 100%
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