Perspectives on oral squamous cell carcinoma prevention — proliferation, position, progression and prediction

Thomson, P.J. (2018) Perspectives on oral squamous cell carcinoma prevention — proliferation, position, progression and prediction. Journal of Oral Pathology and Medicine, 47 (9). pp. 803-807.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: https://doi.org/10.1111/jop.12733
 
84
1


Abstract

Squamous cell carcinoma arising from oral mucosal epithelium remains a lethal and deforming disease due to tumour invasion, oro-facial destruction, cervical lymph node metastasis and ultimate blood-borne dissemination. Worldwide, 300 000 new cases are seen each year, with a recent and significant rise in incidence affecting particularly the young. To rationalize perspectives on preventive strategies in oral cancer management, this study addresses a number of fundamental questions regarding carcinogenesis: proliferation—what epithelial cell changes precede tumour development? Position—why are certain oral sites so predisposed to cancer? Progression—why do some precursor lesions progress to invasive carcinoma and others do not? Prediction—how can we predict individual patient and/or lesion behaviour to prevent disease progression? By improving our understanding of oral carcinogenesis, can we thereby facilitate more effective primary, secondary and tertiary preventive strategies and ultimately reduce the global burden of oral squamous cell carcinoma (OSCC)?.

Item ID: 68447
Item Type: Article (Research - C1)
ISSN: 1600-0714
Keywords: oral squamous cell carcinoma, prevention
Copyright Information: © 2018 John Wiley & Sons A/S.
Date Deposited: 28 Jul 2022 02:07
FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320305 Oral and maxillofacial surgery @ 50%
32 BIOMEDICAL AND CLINICAL SCIENCES > 3211 Oncology and carcinogenesis > 321102 Cancer diagnosis @ 50%
SEO Codes: 20 HEALTH > 2001 Clinical health > 200101 Diagnosis of human diseases and conditions @ 50%
20 HEALTH > 2001 Clinical health > 200104 Prevention of human diseases and conditions @ 50%
Downloads: Total: 1
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page